North Wilkesboro is a very small town located in the state of North Carolina. With a population of 4,280 people and five associated neighborhoods, North Wilkesboro is the 188th largest community in North Carolina.

A relatively large number of people in North Wilkesboro telecommute to their jobs. Overall, about 11.81% of the workforce works from home. While this may seem like a small number, as a fraction of the total workforce it ranks among the highest in the country. These workers are often telecommuters who work in knowledge-based, white-collar professions. For example, Silicon Valley has large numbers of people who telecommute. Other at-home workers may be self-employed people who operate small businesses out of their homes.

Being a small town, North Wilkesboro does not have a public transit system used by locals to get to and from work.

The percentage of people in North Wilkesboro who are college-educated is somewhat higher than the average US community of 21.84%: 26.10% of adults in North Wilkesboro have at least a bachelor's degree.

The per capita income in North Wilkesboro in 2022 was $31,753, which is upper middle income relative to North Carolina, and middle income relative to the rest of the US. This equates to an annual income of $127,012 for a family of four. However, North Wilkesboro contains both very wealthy and poor people as well.

North Wilkesboro is a very ethnically-diverse town. The people who call North Wilkesboro home describe themselves as belonging to a variety of racial and ethnic groups. The greatest number of North Wilkesboro residents report their race to be White, followed by Black or African-American. Important ancestries of people in North Wilkesboro include English, German, Irish, Scottish, and Scots-Irish.

The most common language spoken in North Wilkesboro is English. Other important languages spoken here include Spanish and Italian.